With eStreamDesk you can forward as many e-mails as you need to your account - email@example.com, firstname.lastname@example.org, email@example.com, etc.
To dynamically add labels to the tickets created you simply add the label to your eStreamDesk e-mail address. For example you might want to forward firstname.lastname@example.org to email@example.com. This way all tickets created from firstname.lastname@example.org will have the label "sales" applied to them.
Once your e-mail forwarding is configured you can apply different rules based on the labels of your tickets. You can easily assign tickets with "sales" label to your Sales department, tickets with "support" label to your Support department and so on.